Danaher Accelerates CRISPR Breakthrough Using DBS, Treats Infant in Record Time
SHERIDAN, WYOMING – May 17, 2025 – Danaher Corporation has achieved a historic milestone in genomic medicine, enabling the development and delivery of the world’s first personalized mRNA-based CRISPR therapy for an infant with a life-threatening genetic disorder—in under six months. Powered by the Danaher Business System (DBS), this breakthrough exemplifies how disciplined innovation and cross-company collaboration can dramatically accelerate biopharmaceutical timelines and patient impact.
Compressing an 18-Month Timeline into Six
The urgency was real: an infant diagnosed with neonatal-onset CPS1 deficiency—a rare urea cycle disorder causing fatal ammonia accumulation—needed a cure in weeks, not years. DBS, Danaher’s proprietary system of operational tools and methodologies, allowed teams to strip away inefficiencies and take bold, calculated action.