United States – October 29, 2026 -- A Path2Response-modeled campaign for a global medical aid charity scored 293 on the Response Rate Index, nearly triple the campaign average of 100, according to three client case studies from the firm.
Health and advocacy nonprofits face rising acquisition costs when they scale prospecting beyond small batches. Conventional list rentals and basic donor exchanges produce diminishing returns, the case studies state. Path2Response instead builds lookalike audiences from daily donor data and multichannel transaction data.
Medical aid charity holds response levels across three campaigns
Path2Response modeled a large target universe using donation and transaction histories spanning hundreds of millions of US consumers. It proposed a depth-testing approach to show rollout potential in a near-term timeframe.
The client rolled out at substantial scale. Response Rate Index performance held strong across three separate campaigns, including the 293 result. That consistency, rather than a single successful test, gave the client confidence to keep scaling.
Health advocacy group keeps gift size intact as audience volume grows
A health advocacy organization running research, education and intervention programs needed a repeatable source of new donors. Path2Response built predictive models that weighed philanthropic participation, broader consumer spending behavior and giving cadence.
The organization tested top-tier prospect segments alongside broader depth-test segments. A segment with an income-per-piece-mailed (IPPM) index of 195 generated nearly double the typical income per piece mailed. Performance held as volume grew, and scaling did not dilute gift size or response quality.
Women's rights organization posts positive ROI on expansion segments
An international organization advancing women's rights and clinical health services needed direct mail and digital campaigns to work together without hurting profitability or return on ad spend. Path2Response used cooperative transaction data from its database to run audience expansion tests.
The model found responsive prospects that standard affinity lists missed. Both the core audience and the newly modeled expansion segments delivered positive ROI, which opened the way to a significant rollout and continued donor file growth.