Ionis Pharmaceuticals

Up to 1.55M US Adults With Severe High Triglycerides Undiagnosed

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Up to 1.55M US Adults With Severe High Triglycerides Undiagnosed

Boulder – November 06, 2026 -- An estimated 3.29 to 3.98 million U.S. adults have severe hypertriglyceridemia, but only 2.43 to 2.88 million have been diagnosed, according to a white paper released by the National Triglyceride Alliance. The gap implies roughly 0.86 to 1.10 million adults who are undiagnosed.

The paper, titled "Hidden in Plain Sight: The Unseen Burden of Very High Triglycerides," was supported by Ionis Pharmaceuticals. Patient, care partner, clinical and advocacy contributors helped develop it. It defines the condition as triglycerides of 500 mg/dL or higher.