TPX-100 Data Tie Knee Bone Shape to Meniscal Damage at ACR 2026
FOSTER CITY – November 10, 2026 -- OrthoTrophix reported that femoral bone shape stabilized in knees treated with its osteoarthritis candidate TPX-100, while it kept changing in placebo-treated knees, according to two posters presented at ACR Convergence 2026 in Orlando (November 6-11).
MRI analysis links B-score to meniscal pathology
Poster #1581, presented November 9, is a retrospective MRI analysis of a one-year, double-blind Phase 2a study of intra-articular TPX-100 in knee osteoarthritis (KOA). Femoral bone shape, measured by B-score, was significantly associated with baseline meniscal pathology at 6 and 12 months.
In placebo-treated knees, the bone-meniscus link strengthened over time. In TPX-100-treated knees, bone shape stabilized and the link weakened. The company says this suggests TPX-100 may alter the structural course of KOA in patients with high meniscal disease burden.