Fullerton – November 06, 2026 -- Esperto Medical, Inc., a critical care and remote patient monitoring startup, has received a grant from the Translational Research Institute for Space Health (TRISH) to adapt its Resonance Sonomanometry (RSM) technology for microgravity and other extreme environments.
RSM measures arterial pressure with sound waves and needs no calibration
RSM uses sound waves at different frequencies to measure blood pressure directly within arteries. Esperto says this avoids the variability of other approaches. The system requires no calibration, which simplifies setup and use.
Platform targets three autonomous data streams for astronaut monitoring
Esperto's RSM technology is designed to assess the following autonomously:
- Venous flow and thrombosis risk: characterizes central venous blood flow patterns in the internal jugular vein (IJV) to evaluate thrombosis risk.
- Continuous hemodynamics: measures beat-to-beat blood pressure directly, plus pulse rate and respiration rate.
- Vascular structure: assesses arterial stiffness, wall thickness and vessel radius.
Microgravity physiology drives demand for continuous venous monitoring
Spaceflight triggers cephalad fluid shifts, arterial stiffening and cardiovascular deconditioning. The discovery of IJV thrombosis in astronauts highlighted the need to monitor central venous flow patterns so that spaceflight-associated risks can be detected and managed early.
Esperto aims to carry spaceflight gains into critical care and remote medicine
Dr. Alaina Brinley Rajagopal, Chief Medical Officer and Co-Founder of Esperto Medical, said space monitoring requires technology that is "compact, highly accurate, and completely autonomous." She said standard blood pressure cuffs and invasive lines have clear operational and clinical limitations on long-duration missions.
According to Rajagopal, the TRISH support lets Esperto optimize its ultrasound platform for astronauts while accelerating innovations for critical care, remote medicine and underserved patients on Earth. TRISH is funded by NASA's Human Research Program.