ROCHESTER — November 13, 2026 -- The Mayo Clinic Board of Trustees has elected Matthew R. Callstrom, M.D., Ph.D., to succeed Gianrico Farrugia, M.D., as president and CEO of Mayo Clinic. Farrugia stays in the role through Dec. 31, 2026, which gives the two executives an overlap of about 48 days from the Nov. 13 announcement, by our calculation.
The successor is an internal candidate. Callstrom joined Mayo Clinic in 2002, 24 years before the year of the handover.
Callstrom already sits on two governing boards and runs the AI Program
Callstrom is a member of Mayo Clinic's Board of Governors and of the Board of Trustees that announced his election. He serves as medical director for Mayo Clinic Strategy and the AI Program. He previously was interim chief strategy officer and chair of the Department of Radiology at Mayo Clinic in Rochester.
He is a body interventional radiologist whose work on image-guided cancer treatment has produced more than 200 publications and patents, according to the company. He is a former president of the Society of Interventional Oncology. He holds degrees in chemical engineering and chemistry from the University of Minnesota Twin Cities, completed a postdoctoral fellowship at Harvard University and earned his medical degree at Mayo Clinic Alix School of Medicine.
Farrugia's tenure since 2019 produced the Bold. Forward. strategy and Mayo Clinic Platform
Farrugia has been president and CEO since 2019. Under him, Mayo Clinic launched Bold. Forward., a strategy built on accelerating the discovery, translation and delivery of cures, connecting people with data, and transforming care delivery. The company describes Mayo Clinic Platform, created under that strategy, as its first comprehensive, scalable, AI-enabled care transformation platform.
Board chair Richard K. Davis credited Farrugia with significant investments in people, physical and digital infrastructure, education, research, AI and new care models. The board has chosen a successor who already directs the AI Program, while the outgoing CEO's flagship platform is AI-enabled.
Callstrom says he intends to build on that foundation by accelerating the translation of discovery and emerging technologies into care and extending Mayo Clinic's reach to more patients.
Mayo Clinic did not state the date on which Callstrom's term as president and CEO begins.