OncoHost Plasma Test Flags NSCLC Resistance 170 Days Before Imaging
Binyamina – November 05, 2026 -- OncoHost's 22-protein plasma signature detected acquired immunotherapy resistance in advanced non-small cell lung cancer (NSCLC) a median of 170 days, about 5.6 months, before radiologic progression, according to data the company will present at the International Society of Liquid Biopsy (ISLB) meeting in Madrid on November 7-9.
Two-cohort study analyzes 440 serial plasma samples from 109 patients
The abstract, titled "Longitudinal plasma proteomic profiling predicts immunotherapy response dynamics and overall survival (OS) in NSCLC," validates the signature as a tool for tracking treatment response over time. Researchers analyzed 440 serial plasma samples from 109 patients across two independent cohorts. Patients received immune checkpoint inhibitor (ICI) monotherapy, ICI plus chemotherapy, or dual ICI therapy.