Chonnam Scientists Turn Common Solvent Dichloromethane into Amide Coupling Reagent
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Jeollanam-do – September 25, 2026 -- Researchers at Chonnam National University have demonstrated that dichloromethane, a widely used industrial solvent, can directly drive amide bond formation between carboxylic acids and amines, offering manufacturers a cheaper and less hazardous alternative to conventional coupling reagents. The findings, led by Professor Sunwoo Lee of the Department of Chemistry, were published online on July 6, 2026, and appeared in Volume 148, Issue 27 of the Journal of the American Chemical Society on July 15, 2026.